Philippe St-Pierre Selected Research

PF-4708671

1/2019	Inhibition of mitochondrial complex 1 by the S6K1 inhibitor PF-4708671 partly contributes to its glucose metabolic effects in muscle and liver cells.
3/2016	Pharmacological inhibition of S6K1 increases glucose metabolism and Akt signalling in vitro and in diet-induced obese mice.

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Philippe St-Pierre Research Topics

Disease

13	Insulin Resistance 01/2022 - 05/2004
10	Obesity 01/2024 - 05/2015
7	Inflammation (Inflammations) 01/2024 - 06/2014
6	Body Weight (Weight, Body) 11/2021 - 05/2006
5	Glucose Intolerance 01/2018 - 05/2014
3	Type 2 Diabetes Mellitus (MODY) 01/2024 - 06/2014
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2021 - 07/2015
2	Hyperinsulinism (Hyperinsulinemia) 07/2020 - 05/2014
2	Dyslipidemias (Dyslipidemia) 07/2015 - 05/2011
1	Fibrosis (Cirrhosis) 01/2024
1	Fatty Liver 01/2022
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2021
1	Weight Loss (Weight Reduction) 12/2020
1	Metabolic Diseases (Metabolic Disease) 01/2020
1	Hypertriglyceridemia 05/2014
1	Hyperglycemia 05/2014
1	Hyperlipidemias (Hyperlipidemia) 06/2012
1	Hepatocellular Carcinoma (Hepatoma) 05/2011
1	Atherosclerosis 05/2011
1	Exsanguination 05/2006
1	Hypertension (High Blood Pressure) 05/2004

Drug/Important Bio-Agent (IBA)

12	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 05/2011
9	Insulin (Novolin)FDA Link 01/2024 - 05/2004
5	LipidsIBA 01/2024 - 06/2012
3	10,17- dihydroxydocosa- 4,7,11,13,15,19- hexaenoic acidIBA 01/2021 - 06/2014
3	Mechanistic Target of Rapamycin Complex 1IBA 01/2021 - 03/2016
3	Fatty Acids (Saturated Fatty Acids)IBA 01/2021 - 06/2014
3	PolyphenolsIBA 12/2020 - 01/2018
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 11/2021 - 05/2015
2	Sucrose (Saccharose)IBA 01/2021 - 07/2020
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2015
2	Docosahexaenoic AcidsIBA 01/2021 - 01/2017
2	FructoseIBA 07/2020 - 05/2004
2	PF-4708671IBA 01/2019 - 03/2016
2	C-PeptideIBA 01/2018 - 05/2014
2	Triglycerides (Triacylglycerol)IBA 01/2018 - 05/2006
2	Interleukin-6 (Interleukin 6)IBA 01/2017 - 06/2014
2	TOR Serine-Threonine KinasesIBA 03/2016 - 06/2012
2	Sirolimus (Rapamycin)FDA Link 03/2016 - 05/2014
2	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 05/2015 - 06/2012
1	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2024
1	Cholecalciferol (Vitamin D3)FDA Link 11/2021
1	Fish OilsIBA 01/2021
1	Caseins (Casein)FDA Link 01/2021
1	Dietary Fats (Dietary Fat)IBA 01/2021
1	Dietary ProteinsIBA 01/2021
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2021
1	17- hydroxy- 4,7,10,13,15,19- docosahexaenoic acidIBA 01/2021
1	Persistent Organic PollutantsIBA 12/2020
1	XenobioticsIBA 12/2020
1	SugarsIBA 07/2020
1	Sweetening Agents (Sweeteners)IBA 07/2020
1	SolutionsIBA 07/2020
1	CarbohydratesIBA 07/2020
1	PowdersIBA 01/2020
1	70-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA 01/2019
1	EndotoxinsIBA 01/2018
1	Immunoglobulin G (IgG)IBA 01/2018
1	TP-113IBA 01/2017
1	Metformin (Glucophage)FDA LinkGeneric 01/2017
1	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 03/2016
1	Phosphatidylinositols (Phosphatidylinositol)IBA 03/2016
1	CytokinesIBA 07/2015
1	Peptides (Polypeptides)IBA 07/2015
1	ChemokinesIBA 07/2015
1	Fish ProteinsIBA 07/2015
1	Apolipoprotein B-100 (Apo B 100)IBA 07/2015
1	MyokinesIBA 06/2014
1	SecretagoguesIBA 06/2014
1	Rosiglitazone (Avandia)FDA Link 05/2014
1	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 06/2012
1	nobiletinIBA 05/2011
1	very low density lipoprotein triglycerideIBA 05/2011
1	ApolipoproteinsIBA 05/2011
1	FlavonoidsIBA 05/2011
1	Lipoproteins (Lipoprotein)IBA 05/2011
1	alpha-methylserotoninIBA 06/2009
1	Vasoconstrictor AgentsIBA 06/2009
1	formamideIBA 05/2006
1	Hormones (Hormone)IBA 05/2004

Therapy/Procedure

2	Fat-Restricted Diet (Diet, Fat Restricted) 12/2020 - 05/2015
1	Fecal Microbiota Transplantation 01/2020
1	Therapeutics 06/2014